GM-CSF INCREASES MUCOSAL AND SYSTEMIC IMMUNOGENICITY OF AN H1N1 INFLUENZA DNA VACCINE ADMINISTERED INTO THE EPIDERMIS OF NON-HUMAN PRIMATES.

GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates.

The recent H5N1 avian and H1N1 swine-origin influenza virus outbreaks reaffirm that the threat of a world-wide influenza pandemic is both real and ever-present.Vaccination is still considered the best strategy for protection against influenza virus infection but a significant challenge is to identify new vaccine approaches that offer accelerated pr

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Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

Hematopoiesis is regulated by the bone marrow (BM) stroma.However, cellular identities and functions of the different BM stromal elements in humans remain poorly defined.Based on single-cell RNA sequencing (scRNAseq), we systematically characterized the human non-hematopoietic BM stromal compartment and we investigated stromal cell regulation princ

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